COVID Vaccine scorecard: the latest

The COVID context is changing rapidly with the virus mutating and vaccination programs being rolled out globally. The original evidence on vaccine trials still stands. Here is a summary of what we know to date, which is supported by research evidence and not baseless assertion nor media factoid. As always, the primary references are available – for the sake of easy reading of the table, please refer to my previous posts on COVID 19 to locate the direct links.

Get the vaccine if you can

A note about the table terminology. “Conclusive evidence” means that the majority of reputable publications support this assertion. “Hung  jury” acknowledges that there are differing research findings in the reputable literature and that a clear consensus has yet to emerge. “Not enough evidence” highlights areas where there is a paucity of research and most assertions are anecdotal.

TopicConclusive EvidenceHung JuryNot enough evidence
Newer COVID strains are more infectiousYes. The newer strains spread more rapidly  
Newer COVID strains are more fatalUnknown There is not enough evidence to say whether the newer strains are more likely to cause serious illness or fatalities
All approved vaccines provide protection against COVID transmissionNoThere is some evidence that the Janssen vaccine prevents transmission. None of the other vaccines have released this type of data 
All approved vaccines have been shown to decrease the severity of a COVID infectionYes There is not enough evidence to say whether the relative rates of infection after vaccination make any difference to long term outcomes such as morbidity or reinfection 
All the vaccines are the sameNo. Some are based on parts of the COVID proteins, others on similar viruses, others on immune stimulatory mechanisms. However, they are all developed to  work to stimulate our immune systems to be better prepared against the effects of COVID  
Some vaccines are likely to result in allergic reactionsYes.  There is data that some recipients of the Pfizer vaccine have had allergic reactionsNone of the other vaccines have released this type of data 
Some vaccines work better than others to prevent infectionUnknownNone of the vaccines have released reliable data that is comparable. 
Some vaccines work better than others to limit the course of a COVID illnessUnknown
Most of the research on effectiveness has focussed on how good a given vaccine is at helping us mount our own immune response, or minimise the course of the initial infection or minimize the likelihood for progression from mild to serious or life-threatening disease effectiveness 
Vaccines all require two doses to workNo. The most widely approved vaccines in the Western medicine world – Pfizer, Modern and Astra-Zeneca were trialled with two doses separated by weeks. The Janssen vaccine and some of the Russian and Chinese vaccines have been trialled with one dose onlyThere is emerging evidence that one dose of any vaccine may be enough. This may allow more people to be vaccinated if there are limited supplies 

In conclusion, all the available vaccines at least reduce the severity of COVID symptoms if one is infected and may decrease transmission.  This is reason enough to get the vaccine if you can.

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